Sequentially updating the likelihood of success of a Phase 3 pivotal time-to-event trial based on interim analyses or external information
Purpose | Setup | Define the prior distributions | Computation of all quantities in Table 1, and all the figures | Interesting probabilities | BPP at the beginning of the trial | Update the prior distribution with external information | Update the prior distribution after not stopping at an interim analysis | Posterior densities | Table 1 in @rufibach_14 | Update of BPP when not stopping the trial in two blinded interim analyses | Info | References
Rendered frombpp.Rmdusingknitr::rmarkdown